Method for analyzing biological substances in a co

专利名称：Method for analyzing biological substances

in a conductive liquid medium

发明人：Jean-Rene Martin,Eliane Souteyrand,Marcus

Francois Lawrence,Susan Rosalie Mikkelsen

申请号：US09/1379申请日：19980821公开号：US06150106A公开日：20001121

摘要：The present invention relates to a procedure for the qualitative and/or

quantitative analysis of biological substances, which are preferably biological substances,that are present in a conductive liquid medium, with the aid of at least one affinity sensorthat includes at least one structure that includes at least one semiconductor material,which is coated on one of its surface with at least one layer of an isolating material, whichin turn is affixed adhesively to at least one sensitive membrane, which is in contact withthe conductive medium and which includes ligands that are complementary to thebiological substances in question and which are capable of, and suitable for, forming pairsspecifically with the latter biological substances, with the said procedure beingcharacterized by the fact that it consists essentially of applying a voltage between thesemiconductor and the conductive medium; of gathering the variations in the electricalsignals induced by a charge- effect phenomenon directly and essentially linked to thespecific pairings of the biological substances with their complementary ligands includedin the sensitive membrane; and interpreting the collected signals in order to identifyand/or quantify the substances in question.

申请人：MARTIN; JEAN-RENE,SOUTEYRAND; ELIANE,LAWRENCE; MARCUSFRANCOIS,MIKKELSEN; SUSAN ROSALIE

代理机构：Pillsbury Madison & Sutro LLP

更多信息请下载全文后查看