Intermediates and improved processes for the prepa

专利名称：Intermediates and improved processes for

the preparation of neplanocin A

发明人：Naoyuki Yoshida,Kunio Ogasawara申请号：US10369686申请日：20030221公开号：US07053225B2公开日：20060530

摘要：Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.0]dec-8-ene, which are useful for thesynthesis of neplanocin A having strong antitumor activity. Improved processes for thepreparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.0]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reactionof the above intermediate.

申请人：Naoyuki Yoshida,Kunio Ogasawara

地址：Ichihara JP,Sendai JP

国籍：JP,JP

代理机构：McDermott Will & Emery LLP

更多信息请下载全文后查看